NCBI Conserved Domain Database predictions

Reversed Position Specific Blast (RPSBLAST) was used to search the Conserved Domain Database (CDD) of position-specific scoring matrices (PSSMs) representing a collection of well-annotated multiple sequence alignment models for ancient domains and full-length proteins. The PSSMs are available from the NCBI ftp site at The best RPSBLAST hit for each query amino acid sequence using a cutoff value of 1E-4 was taken.